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The fatal detachment

Nature Cell Biology volume 3, pages E157–E158 (2001)Cite this article

No mutation in the fibroblast-growth-factor receptor-4 (FGFR-4) signalling pathway has so far been associated with either heritable human diseases or cancer. A new study now implicates N-CAM–FGFR-4 signalling in the regulation of tumour-cell–matrix adhesion and in the metastatis of pancreatic β-cell tumours.

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Figure 1: Model of N-CAM-mediated signal transduction in pancreatic Langerhans islet β-cells.

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Authors and Affiliations

  1. Molecular/Cancer Biology Laboratory, Biomedicium Helsinki, Haartmaninkatu 8, 00014

    Kari Alitalo

  2. University of Helsinki, Finland

    Kari Alitalo

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  1. Kari Alitalo
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Alitalo, K. The fatal detachment. Nat Cell Biol 3, E157–E158 (2001). https://doi.org/10.1038/35083104

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