The fatal detachment

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No mutation in the fibroblast-growth-factor receptor-4 (FGFR-4) signalling pathway has so far been associated with either heritable human diseases or cancer. A new study now implicates N-CAM–FGFR-4 signalling in the regulation of tumour-cell–matrix adhesion and in the metastatis of pancreatic β-cell tumours.

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Figure 1: Model of N-CAM-mediated signal transduction in pancreatic Langerhans islet β-cells.

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