Straight or split: signals to transcription

Since the discovery of substances in serum media that are able to drive cells into proliferation and/or differentiation, investigators have tried to understand how such signalling molecules can influence cells to change their behaviour. The complex nature of the responses to signals, and the equally complex signalling pathway leading to those responses, have made life difficult for the researcher. However, recent evidence obtained in genetic developmental systems indicates that a multiplicity of downstream events can be accomplished by regulation of the activity of just one transcription factor.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Drawing showing the various forms of Cubitus interruptus protein (Ci) present as transcriptional regulators of hedgehog (hh) target genes.

References

  1. 1

    Massagué, J. Cell 49, 437–438 (1987).

  2. 2

    Gospodarowicz, D., Ferrara, N., Schweigerer, L. & Neufeld, G. Endocr. Rev. 8, 95–114 (1987).

  3. 3

    Nusse, R. Trends Genet. 2, 244–247 (1988).

  4. 4

    Spemann, H. & Mangold, H. Archiv. Mikr. Ent. Mech. 100, 599–638 (1923).

  5. 5

    Nieuwkoop, P. D. Wilh. Roux Arch. 162, 341–373 (1969).

  6. 6

    Slack, J. M. W., Darlington, B. G., Heath, J. K. & Godsave, S. F. Nature 326, 197–200 (1987).

  7. 7

    Smith, J. Development 99, 3–14 (1987).

  8. 8

    Rijsewijk, F., Schuermann, M, Wagenaar, E., Parren, P., Weigel, D. & Nusse, R. Cell 50, 649–657 (1987).

  9. 9

    Hall, A. C., Lucas, F. R. & Salinas, P. C. Cell 100, 525–535 (2000).

  10. 10

    Methot, N. & Basler, K. Development 128, 733–742 (2001).

  11. 11

    Dominguez, M., Brunner, M., Hafen, E. & Basler, K. Science 272, 1621–1625 (1996).

  12. 12

    Aza, B. P., Ramirez, W. F., Laget, M. P., Schwartz, C. & Kornberg, T. B. Cell 89, 1043–1053 (1997).

  13. 13

    Ohlmeyer, J. T. & Kalderon, D. Nature 396, 749–753 (1998).

  14. 14

    Alexandre, C., Jacinto, A. & Ingham, P. W. Genes Dev. 10, 2003–2013 (1996).

  15. 15

    Muller, B. & Basler, K. Development 127, 2999–3007 (2000).

  16. 16

    Aza_Blanc, P., Lin, H. Y., Ruiz I Altaba, A. & Kornberg, T. B. Development 127, 4293–4301 (2000).

  17. 17

    Wang, B., Fallon, J. F. & Beachy, P. A. Cell 100, 423–434 (2000).

  18. 18

    Biesecker, L. G. Strike three for GLI3. Nature Genet. 17, 259–260 (1997).

  19. 19

    van den Heuvel, M. Signal transduction pathways in development: Hedgehog proteins and their receptors. In Encyclopedia of Life Sciences (http://www.els.net) (2000).

  20. 20

    Capdevila, J. Hedgehog signalling. In Encyclopedia of Life Sciences (http://www.els.net) (2000).

  21. 21

    Cavallo, R. A. et al. Nature 395, 604–608 (1998).

  22. 22

    Morel, V. & Schweisguth, F. Genes Dev. 14, 377–388 (2000).

  23. 23

    Wotton, D., Lo, R. S., Lee, S. & Massagué, J. Cell 97, 29–39 (1999).

  24. 24

    Wehrli, M. et al. Nature 407, 527–530 (2000).

  25. 25

    Mao, B. et al. Nature 411, 321–325 (2001).

  26. 26

    Krause, D. S. et al. Cell 105, 369–377 (2001).

Download references

Acknowledgements

I thank Jennie Brown for helpful comments on my writing.

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading