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Caspase activity sows the seeds of neuronal death

Abstract

Caspases, proteases involved in programmed cell death, may have a role in Alzheimer’s and Huntington’s diseases. Localized caspase activation and apoptosis may be linked to the initiation of such chronic neurodegenerative diseases.

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Figure 1: Caspase-mediated cleavage of amyloid precursor protein (APP) and Huntingtin protein promotes the formation of cell-toxic protein fragments (red), leading to cell death.

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Correspondence to Junying Yuan.

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Yuan, J., Yankner, B. Caspase activity sows the seeds of neuronal death. Nat Cell Biol 1, E44–E45 (1999). https://doi.org/10.1038/10037

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