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Cholesterol: stuck in traffic

Nature Cell Biology volume 1, pages E37–E38 (1999)Cite this article

Abstract

Niemann–Pick type C is a genetic disorder thought to be partly characterized by a defect in cholesterol storage in lysosomes. New findings show that in fact cholesterol accumulates in late endosomes, and this accumulation leads to the redistribution of membrane proteins.

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Figure 1: Trafficking pathways in a nonpolarized cell such as a fibroblast.

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Authors and Affiliations

  1. Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, 10021 , New York, USA

    Sushmita Mukherjee & Frederick R. Maxfield

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  1. Sushmita Mukherjee
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  2. Frederick R. Maxfield
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Correspondence to Frederick R. Maxfield.

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Mukherjee, S., Maxfield, F. Cholesterol: stuck in traffic. Nat Cell Biol 1, E37–E38 (1999). https://doi.org/10.1038/10030

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