Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cholesterol: stuck in traffic

Abstract

Niemann–Pick type C is a genetic disorder thought to be partly characterized by a defect in cholesterol storage in lysosomes. New findings show that in fact cholesterol accumulates in late endosomes, and this accumulation leads to the redistribution of membrane proteins.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Trafficking pathways in a nonpolarized cell such as a fibroblast.

References

  1. Kobayashi, T. et al. Nature Cell Biol. 1, 113– 118 (1999).

    Article  CAS  Google Scholar 

  2. Neufeld, E. B. et al. J. Biol. Chem. 274, 9627– 9635 (1999).

    Article  CAS  Google Scholar 

  3. Mukherjee, S., Ghosh, R. N. & Maxfield, F. R. Physiol. Rev. 77, 759– 803 (1997).

    Article  CAS  Google Scholar 

  4. Simons, K. & Ikonen, E. Nature 387, 569–572 (1997).

    Article  Google Scholar 

  5. Mukherjee, S., Soe, T. T. & Maxfield, F. R. J. Cell Biol. 144, 1271– 1284 (1999).

    Article  Google Scholar 

  6. Kobayashi, T. et al. Nature 392, 193–197 (1998).

    Article  Google Scholar 

  7. Liscum, L. & Klansek, J. J. Curr. Opin. Lipidol. 9, 131–135 (1998).

    Article  CAS  Google Scholar 

  8. Mayor, S., Sabharanjak, S. & Maxfield, F. R. EMBO J. 17, 4626– 4638 (1998).

    Article  CAS  Google Scholar 

  9. Rodal, S. K. et al. Mol. Biol. Cell 10, 961– 974 (1999).

    Article  CAS  Google Scholar 

  10. Subtil, A. et al. Proc. Natl. Acad. Sci. USA (in the press).

  11. Tabas, I. Curr. Opin. Lipidol. 6, 260–268 (1995).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Frederick R. Maxfield.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mukherjee, S., Maxfield, F. Cholesterol: stuck in traffic. Nat Cell Biol 1, E37–E38 (1999). https://doi.org/10.1038/10030

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/10030

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing