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Cholesterol: stuck in traffic


Niemann–Pick type C is a genetic disorder thought to be partly characterized by a defect in cholesterol storage in lysosomes. New findings show that in fact cholesterol accumulates in late endosomes, and this accumulation leads to the redistribution of membrane proteins.

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Figure 1: Trafficking pathways in a nonpolarized cell such as a fibroblast.


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Correspondence to Frederick R. Maxfield.

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Mukherjee, S., Maxfield, F. Cholesterol: stuck in traffic. Nat Cell Biol 1, E37–E38 (1999).

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