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Caveolin, cholesterol and Ras signalling


Studies on the role of cholesterol- and caveolin-rich membrane microdomains in localizing Ras to the plasma membrane and enabling its signalling activity reveal intriguing differences both between mammalian H-Ras and K-Ras and between requirements for Ras signalling in mammalian and nematode cells.

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Figure 1: Membrane microdomains and signal transduction.
Figure 2: Caveolin, Ras and meiotic progression in C. elegans.


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Correspondence to Paul W. Sternberg.

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Sternberg, P., Schmid, S. Caveolin, cholesterol and Ras signalling . Nat Cell Biol 1, E35–E37 (1999).

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