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How BAD phosphorylation is good for survival


BAD is a pro-apoptotic member of the Bcl-2 family that is tightly regulated by survival factors. Several major signalling pathways influence cell death through their direct effects on the phosphorylation state of BAD.

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Figure 1: Regulation of BAD phosphorylation.


  1. Korsmeyer, S. J. Cancer Res. 59 (suppl.), 1693–1700 (1999).

    Google Scholar 

  2. Downward, J. Curr. Opin. Cell Biol. 10, 262–267 (1998).

    Article  Google Scholar 

  3. Harada, H. et al. Mol. Cell 3, 413–422 (1999).

    Article  Google Scholar 

  4. Wang, H. G. et al. Science 284, 339–343 (1999).

    Article  Google Scholar 

  5. Yang, E. et al. Cell 80, 285–291 (1995).

    Article  Google Scholar 

  6. Zha, J., Harada, H., Yang, E., Jockel, J. & Korsmeyer, S. J. Cell 87, 619– 628 (1996).

    Article  Google Scholar 

  7. Datta, S. R. et al. Cell 91, 231–241 (1997).

    Article  Google Scholar 

  8. del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R. & Nunez, G. Science 278, 687–689 (1997).

    Article  Google Scholar 

  9. Blume-Jensen, P., Janknecht, R. & Hunter, T. Curr. Biol. 8, 779– 782 (1998).

    Article  Google Scholar 

  10. Kitada, S. et al. Am. J. Pathol. 152, 51– 61 (1998).

    Google Scholar 

  11. Cardone, M. H. et al. Science 282, 1318– 1321 (1998).

    Article  Google Scholar 

  12. Brunet, A. et al. Cell 96, 857–868 (1999).

    Article  Google Scholar 

  13. Wang, H. G., Rapp, U. R. & Reed, J. C. Cell 87, 629– 638 (1996).

    Article  Google Scholar 

  14. Scheid, M.P. & Duronio, V. Proc. Natl Acad. Sci. USA 95, 7439–7444 (1998).

    Article  Google Scholar 

  15. Yano, S., Tokumitsu, H. & Soderling, T. R. Nature 396, 584– 587 (1998).

    Article  Google Scholar 

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Correspondence to Julian Downward.

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Downward, J. How BAD phosphorylation is good for survival. Nat Cell Biol 1, E33–E35 (1999).

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