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Wnt signalling escapes to cilia

Nature Cell Biology volume 13, pages 636637 (2011) | Download Citation

The primary cilium is proposed to restrain the level of canonical Wnt signalling, but it was unknown how the cilium achieves this. β-catenin, a component of the canonical Wnt signalling pathway, is now shown to be sequestered to the cilium by the Wnt signalling modulator Jouberin (Jbn) to restrain Wnt responses.

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Author information

Affiliations

  1. Rieko Ajima and Hiroshi Hamada are in the Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and CREST, Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan

    • Rieko Ajima
    •  & Hiroshi Hamada

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Hiroshi Hamada.

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DOI

https://doi.org/10.1038/ncb0611-636

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