The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.
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References
Vousden, K. H. & Lane, D. P. Nature Rev. Mol. Cell Biol. 8, 275–283 (2007).
Brensaad, K. & Vousden, K. H. Trends Cell Biol. 17, 286–291 (2007).
Green, D. R. & Chipuck, J. E. Cell 126, 30–32 (2006).
Levine, B. & Kroemer, G. Cell 132, 27–42 (2008).
Feng, Z., Zhang, H., Levine, A. J. & Jin, S. Proc. Natl Acad. Sci. USA 102, 8204–8209 (2005).
Zeng, X., Yan, T., Schupp, J. E., Seo, Y. & Kinsella, T. J. Clin. Cancer Res. 13, 1315–1321 (2007).
Abida, W. M. & Gu, W. Cancer Res. 68, 352–357 (2008).
Crighton, D. et al. Cell 126, 121–134 (2006).
Amaravadi, R. K. et al. J. Clin. Invest. 117, 326–336 (2007).
Maclean, K. H., Dorsey, F. C., Cleveland, J. L. & Kastan, M. B. J. Clin. Invest. 118, 79–88 (2008).
Tasdemir, E. et al. Nature Cell Biol. 10, 676–687 (2008).
Maiuri, M. C., Zalckvar, E., Kimchi, A. & Kroemer, G. Nature Rev. Mol. Cell Biol. 8, 741–752 (2007).
Akdemir, F., Christich, A., Sogame, N., Chapo, J. & Abrams, J. M. Oncogene 26, 5184–5193 (2007).
Bourdon, J. C. et al. Genes Dev. 19, 2122–2137 (2005).
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Levine, B., Abrams, J. p53: The Janus of autophagy?. Nat Cell Biol 10, 637–639 (2008). https://doi.org/10.1038/ncb0608-637
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DOI: https://doi.org/10.1038/ncb0608-637
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