Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The Crm de la crème of mitosis

The small GTPase Ran controls nucleocytoplasmic transport and has multiple roles during cell division. A new study has identified the nuclear export factor Crm1 as a mitotic effector of Ran-GTP at kinetochores, where it has a role in microtubule attachment.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Regulation of multiprotein complexes by Ran-GTP during mitotic spindle assembly.

References

  1. Clarke, P. R. & Zhang, C. Trends Cell Biol. 11, 366–371 (2001).

    CAS  Article  Google Scholar 

  2. Harel, A. & Forbes, D. J. Mol. Cell 16, 319–330 (2004).

    CAS  PubMed  Google Scholar 

  3. Arnaoutov, A. et al. Nature Cell Biol. 7, 626–632 (2005).

    CAS  Article  Google Scholar 

  4. Hutchins, J. R. et al. Curr. Biol. 14, 1099–1104 (2004).

    CAS  Article  Google Scholar 

  5. Li, H. Y. & Zheng, Y. Genes Dev. 18, 512–527 (2004).

    CAS  Article  Google Scholar 

  6. Moore, W. J., Zhang, C. & Clarke, P. R. Curr. Biol. 12, 1442–1447 (2002).

    CAS  Article  Google Scholar 

  7. Karsenti, E. & Vernos, I. Science 294, 543–547 (2001).

    CAS  Article  Google Scholar 

  8. Blower, M. D., Nachury, M., Heald, R. & Weis, K. Cell 121, 223–234 (2005).

    CAS  Article  Google Scholar 

  9. Kalab, P., Weis, K. & Heald, R. Science 295, 2452–2456 (2002).

    CAS  Article  Google Scholar 

  10. Joseph, J., Tan, S. H., Karpova, T. S., McNally, J. G. & Dasso, M. J. Cell Biol. 156, 595–602 (2002).

    CAS  Article  Google Scholar 

  11. Arnaoutov, A. & Dasso, M. Dev. Cell 5, 99–111 (2003).

    CAS  Article  Google Scholar 

  12. Salina, D., Enarson, P., Rattner, J. B. & Burke, B. J. Cell Biol. 162, 991–1001 (2003).

    CAS  Article  Google Scholar 

  13. Joseph, J., Liu, S. T., Jablonski, S. A., Yen, T. J. & Dasso, M. Curr. Biol. 14, 611–617 (2004).

    CAS  Article  Google Scholar 

  14. Tanaka, K. et al. Nature 434, 987–994 (2005).

    CAS  Article  Google Scholar 

  15. Loiodice, I. et al. Mol. Biol. Cell 15, 3333–3344 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Clarke, P. The Crm de la crème of mitosis. Nat Cell Biol 7, 551–552 (2005). https://doi.org/10.1038/ncb0605-551

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0605-551

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing