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The Crm de la crème of mitosis

The small GTPase Ran controls nucleocytoplasmic transport and has multiple roles during cell division. A new study has identified the nuclear export factor Crm1 as a mitotic effector of Ran-GTP at kinetochores, where it has a role in microtubule attachment.

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Figure 1: Regulation of multiprotein complexes by Ran-GTP during mitotic spindle assembly.


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Clarke, P. The Crm de la crème of mitosis. Nat Cell Biol 7, 551–552 (2005).

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