Cdc14 phosphatase resolves the rDNA segregation delay

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Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.

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Figure 1: Segregation of the mitotic chromosomes in budding yeast.

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Pereira, G., Schiebel, E. Cdc14 phosphatase resolves the rDNA segregation delay. Nat Cell Biol 6, 473–475 (2004) doi:10.1038/ncb0604-473

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