Nature Cell Biology, and indeed all other Nature Publishing Group journals, engage in special projects — Focuses, Supplements, Insights and Milestones — that are intended to highlight a journal's continuing commitment to areas of exceptional scientific interest. In this month's issue — a Focus on membrane traffic — we are pleased to present a series of specially commissioned articles by leading experts in the field.
Understanding how proteins are targeted to organelles or for secretion, and how they travel between intracellular compartments, has been an area of intense investigation since cell biology evolved as a discipline. From the largely phenomenological investigations of the 1960s, the field has moved to bolster initial morphological observations with a molecular and structural understanding of the underlying processes. This progression is summarized in a Historical Perspective article by Randy Schekman on page 483. As the field has matured, several fundamental issues have been resolved; nevertheless, the pace of enquiry remains brisk as new questions continue to arise and old ones are revisited. The growing interface between membrane traffic and other areas of cell biology — such as development, signalling, cytokinesis and the cytoskeleton — has contributed to the continued expansion of the field, while also attesting to its immediate relevance to allied topics in cell biology. As in other areas of cell biology, the advent of sophisticated imaging technology has opened up new avenues of study in membrane traffic, which will ensure that the field remains an engaging and vital area of cell biological enquiry for the coming decades. The aim of this collection is not to represent a comprehensive survey of the field, but rather to highlight a cross-section of emerging topics of interest such as regulated exocytosis and the generation of organelle identity.
We hope that this Focus will appeal not only to those directly involved in membrane traffic, but also to readers whose primary interest lies in other areas of cell biology. The Focus articles will be available free online for one month. In addition, these Focus articles will be available on a dedicated website (http://www.nature.com/ncb/webfocus/membrane), which also contains a continuously updated online archive of all relevant material published in Nature Cell Biology since the journal was launched five years ago.
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Spotlight on membrane traffic. Nat Cell Biol 6, 467 (2004). https://doi.org/10.1038/ncb0604-467