In the Drosophila egg, during signalling through the epidermal growth factor (EGF) receptor, a conformational switch, which is dependent on mitogen-activated protein kinase (MAPK) leads to the Cf2 transcriptio-nal repressor being targeted for proteolysis. Recent work shows that this switch is catalysed by the Drosophila homologue of Pin1, a peptidyl-prolyl isomerase.
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Freeman, M. Pin-pointing MAPK signalling. Nat Cell Biol 3, E136–E137 (2001). https://doi.org/10.1038/35078599
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DOI: https://doi.org/10.1038/35078599
