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What goes up must come down

Nature Cell Biology volume 1, pages E10–E11 (1999)Cite this article

Abstract

The activity of the epidermal-growth-factor receptor is highly regulated during Drosophila development. Two negative-feedback loops involving the proteins Kekkon1 and Sprouty have been found to act by quite different inhibitory mechanisms.

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Figure 1: Two different ways of achieving negative-feedback inhibition of receptor tyrosine kinase signalling pathways.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 5BT, UK

    Sally J. Leevers

  2. University College London branch of the Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1P 8BT, UK

    Sally J. Leevers

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  1. Sally J. Leevers
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Correspondence to Sally J. Leevers.

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Leevers, S. What goes up must come down. Nat Cell Biol 1, E10–E11 (1999). https://doi.org/10.1038/8960

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