Phosphorylation of synaptojanin 1 by the EphB2 receptor tyrosine kinase is a molecular switch. This phosphorylation prevents the interaction of synaptojanin 1 with endophilin and promotes endocytosis. Subsequent dephosphorylation initiates an interaction with endophilin, leading to clathrin uncoating and fusion with endosomes.
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Hopper, N., O'Connor, V. Ephrin tempers two-faced synaptojanin 1. Nat Cell Biol 7, 454–456 (2005). https://doi.org/10.1038/ncb0505-454
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DOI: https://doi.org/10.1038/ncb0505-454
