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Tea for three: control of fission yeast polarity

By what molecular mechanisms do microtubules regulate the spatial distribution of actin assembly in cells? In fission yeast, a novel SH3-domain-containing protein, Tea4p, acts to bridge the microtubule plus-end-binding protein Tea1p with the actin-nucleating formin protein For3p.

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Figure 1: Growth patterns in wild-type and tea1Δ and tea4Δ mutant cells.
Figure 2: Model for activation of growth in fission yeast.

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Snaith, H., Sawin, K. Tea for three: control of fission yeast polarity. Nat Cell Biol 7, 450–451 (2005). https://doi.org/10.1038/ncb0505-450

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