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Talin's second persona

Talin is a core component of the integrin adhesion complex. It is now shown that talin also regulates transcription, an activity that is apparently independent of its interaction with integrins. Talin represses the expression of Drosophila melanogaster DE-cadherin through an unknown molecular mechanism.

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Figure 1: Talin regulates the expression of shotgun, which encodes DE-cadherin.

References

  1. Nayal, A., Webb, D. J. & Horwitz, A. F. Curr. Opin. Cell Biol. 16, 94–98 (2004).

    Article  CAS  Google Scholar 

  2. Brown, N. H. et al. Dev. Cell 3, 569–579 (2002).

    Article  CAS  Google Scholar 

  3. Cram, E. J., Clark, S. G. & Schwarzbauer, J. E. J. Cell Sci. 116, 3871–3878 (2003).

    Article  CAS  Google Scholar 

  4. Jiang, G., Giannone, G., Critchley, D. R., Fukumoto, E. & Sheetz, M. P. Nature 424, 334–337 (2003).

    Article  CAS  Google Scholar 

  5. Bécam, I. E., Tanentzapf, G., Lepesant, J.-A., Brown, N. H. & Huynh, J.-R. Nature Cell Biol. 7, 510–516 (2005).

    Article  Google Scholar 

  6. Gonzalez-Reyes, A. & St. Johnston, D. Science 266, 639–642 (1994).

    Article  CAS  Google Scholar 

  7. Godt, D. & Tepass, U. Nature 395, 387–391 (1998).

    Article  CAS  Google Scholar 

  8. Gonzalez-Reyes, A. & St. Johnston, D. Development 125, 3635–3644 (1998).

    CAS  PubMed  Google Scholar 

  9. Oda, H. & Tsukita, S. Dev. Biol. 216, 406–422 (1999).

    Article  CAS  Google Scholar 

  10. Pacquelet, A., Lin, L. & Rorth, P. J. Cell Biol. 160, 313–319 (2003).

    Article  CAS  Google Scholar 

  11. Torres, I. L., Lopez-Schier, H. & St. Johnston, D. Dev. Cell 5, 547–558 (2003).

    Article  CAS  Google Scholar 

  12. Lopez-Schier, H. Bioessays 25, 781–791 (2003).

    Article  Google Scholar 

  13. Balda, M. S. & Matter, K. Trends Cell Biol. 13, 310–318 (2003).

    Article  CAS  Google Scholar 

Download references

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Tepass, U., Godt, D. Talin's second persona. Nat Cell Biol 7, 443–444 (2005). https://doi.org/10.1038/ncb0505-443

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