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A Bit-role for integrins in apoptosis

Nature Cell Biology volume 6, pages 388–389 (2004)Cite this article

Loss of integrin-mediated attachment to the extracellular matrix triggers apoptosis through the activation of caspases. A recent study shows that disruption of integrin function also induces mitochondrial release of Bit1, a caspase-independent effector of apoptosis.

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Figure 1: Regulation of Bit1 during apoptosis.

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Authors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, 92037, CA, USA

    Dwayne G. Stupack & David A. Cheresh

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  1. Dwayne G. Stupack
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  2. David A. Cheresh
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Stupack, D., Cheresh, D. A Bit-role for integrins in apoptosis. Nat Cell Biol 6, 388–389 (2004). https://doi.org/10.1038/ncb0504-388

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