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Deafening cycle

Nature Cell Biology volume 5, pages 385–387 (2003)Cite this article

Hearing loss in mammals occurs when auditory hair cells, specialized in the detection of sound waves, undergo irreversible damage. However, the mechanism, and in particular the genetic basis of the process, is poorly understood. A study in this issue now shows that functional inactivation of the cyclin D-dependent kinase inhibitor Ink4d results in progressive hearing loss in mice, implicating Cdk inhibitors and inappropriate hair cell proliferation in deafness.

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Figure 1: Cdk inhibitors and their role in the development of the Organ of Corti.

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Authors and Affiliations

  1. Program in Cellular and Molecular Biology, One Baylor Plaza, Baylor College of Medicine, Houston, 777030, TX, USA

    Bridget Baumgartner

  2. Department of Biochemistry and Molecular Biology and Department of Molecular Physiology and Biophysics, Program in Cellular and Molecular Biology, One Baylor Plaza, Baylor College of Medicine, Houston, 777030, TX, USA

    J. Wade Harper

Authors
  1. Bridget Baumgartner
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  2. J. Wade Harper
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Baumgartner, B., Harper, J. Deafening cycle. Nat Cell Biol 5, 385–387 (2003). https://doi.org/10.1038/ncb0503-385

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