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AP-1 as a regulator of cell life and death

Abstract

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed.

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Figure 1: A model describing the effects of AP-1 proteins on the major cell cycle regulators.
Figure 2: The effects of c-Jun in apoptosis.

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Shaulian, E., Karin, M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4, E131–E136 (2002). https://doi.org/10.1038/ncb0502-e131

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