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The transcriptional role of PML and the nuclear body

Nature Cell Biology volume 2, pages E85–E90 (2000)Cite this article

Abstract

The PML gene encodes a tumour suppressor protein associated with a distinct subnuclear domain, the nuclear body. Various functions have been attributed to the PML nuclear body, but its main biochemical role is still unclear. Recent findings indicate that PML is essential for the proper formation of the nuclear body and can act as a transcriptional co-factor. Here we summarize the current understanding of the biological functions of PML and the nuclear body, and discuss a role for these intra-nuclear structures in the regulation of transcription.

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Figure 1: PML and nuclear body.
Figure 2: SUMOylated PML is required for the proper formation of nuclear body.
Figure 3: Models of nuclear body-regulated transcription.

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Acknowledgements

We would like to thank all the past and present members of the laboratory of Molecular and Developmental Biology at Memorial Sloan–Kettering Cancer Center, working on PML and related subjects: Maria Barna, Mantu Bhaumik, Laurent Delva, Mirella Gaboli, Domenica Gandini, Marco Giorgio, Ailan Guo, Li-Zhen He, Sundeep Kalantry, Taha Merghoub, Daniela Peruzzi, Roberta Rivi, Simona Ronchetti, Davide Ruggero, Zhu-Gang Wang, Hui Zhang, as well as Letizia Longo in our Department. P.S. is recipient of a ‘doctorate fellowship’ by the Medical School of the University of Modena, Italy. P.P.P. is a Scholar of the Leukemia and Lymphoma Society of America (formerly known as Leukemia Society of America). Our work is supported, by the NCI, the De Witt Wallace Fund for Memorial Sloan–Kettering Cancer centre, and NIH Grants to P.P.P.

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  1. Department of Human Genetics and Molecular Biology Program, Sloan–Kettering Division, Memorial Sloan-Kettering Cancer Center, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, NY 10021, USA

    Sue Zhong, Paolo Salomoni & Pier Paolo Pandolfi

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Zhong, S., Salomoni, P. & Pandolfi, P. The transcriptional role of PML and the nuclear body. Nat Cell Biol 2, E85–E90 (2000). https://doi.org/10.1038/35010583

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