Two papers in this issue show that dynein-binding proteins may regulate the G1–S transition through an effect on cilia. Nde1, a known partner of dynein light chain LC8, controls ciliary length in vitro and in zebrafish, and influences the G1–S progression. The phosphorylation of Tctex1, a dynein light chain, modulates cilia length and accelerates G1–S, thereby regulating proliferation–differentiation decisions in the developing mouse neocortex.
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References
Tucker, R. W., Pardee, A. B. & Fujiwara, K. Cell 17, 527–535 (1979).
Kim, S. et al. Nat. Cell Biol. 13, 351–360 (2011).
Li, A. et al. Nat. Cell Biol. 13, 402–411 (2011).
Pedersen, L. B. & Rosenbaum, J. L. Curr. Top. Dev. Biol. 85, 23–61 (2008).
Nachury, M. V. et al. Cell 129, 1201–13 (2007).
Westlake, C. J. et al. Proc. Natl Acad. Sci. USA 108, 2759–2756 (2011).
Seeley, E. S. & Nachury, M. V. J. Cell Sci. 12 3, 511–518 (2010).
Pugacheva, E. N. et al., Cell 129, 1351–1363 (2007).
Efimov, V. P. & Morris, N. R. J. Cell Biol. 150, 681–688 (2000).
Feng, Y. & Walsh, C. A. Neuron 44, 279–293 (2004).
Pazour, G. J., Wilkerson, C. G. & Witman, G. B. J. Cell Biol. 141, 979–992 (1998).
Gillingham, A. K. & Munro, S. EMBO rep. 1, 524–529 (2000).
Rompolas, P. et al. J. Cell Sci. 120, 3653–3665 (2007).
Alvarez-Bullya, A. et al. Nat. Rev. Neurosci. 2, 287–293 (2001).
Chuang, J. Z. et al. Dev. Cell 9, 75–86 (2005).
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Jackson, P. Do cilia put brakes on the cell cycle?. Nat Cell Biol 13, 340–342 (2011). https://doi.org/10.1038/ncb0411-340
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DOI: https://doi.org/10.1038/ncb0411-340
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