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Abscission accomplished by PtdIns(3)P


Cytokinesis — the final step of mitosis in which the two daughter cells separate — requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.

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Figure 1: Role of FYVE-CENT/KIF13A complex in PtdIns(3)P-endosome dynamics during cytokinesis.


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Montagnac, G., Chavrier, P. Abscission accomplished by PtdIns(3)P. Nat Cell Biol 12, 308–310 (2010).

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