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Abscission accomplished by PtdIns(3)P

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Cytokinesis — the final step of mitosis in which the two daughter cells separate — requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.

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Figure 1: Role of FYVE-CENT/KIF13A complex in PtdIns(3)P-endosome dynamics during cytokinesis.

References

  1. Montagnac, G., Echard, A. & Chavrier, P. Curr. Opin. Cell Biol. 20, 454–461 (2008).

    CAS  Article  Google Scholar 

  2. Echard, A. Biochem. Soc. Trans. 36, 395–399 (2008).

    CAS  Article  Google Scholar 

  3. Sagona, A. P. et al. Nature Cell Biol. 12, 362–371 (2010).

    CAS  Article  Google Scholar 

  4. Lindmo, K. & Stenmark, H. J. Cell Sci. 119, 605–614 (2006).

    CAS  Article  Google Scholar 

  5. Vermeer, J. E. et al. Plant J. 47, 687–700 (2006).

    CAS  Article  Google Scholar 

  6. Falasca, M. & Maffucci, T. Biochim. Biophys. Acta 1793, 1795–1803 (2009).

    CAS  Article  Google Scholar 

  7. Hanein, S. et al. Am. J. Hum. Genet. 82, 992–1002 (2008).

    CAS  Article  Google Scholar 

  8. Kurasawa, Y., Earnshaw, W. C., Mochizuki, Y., Dohmae, N. & Todokoro, K. EMBO J. 23, 3237–3248 (2004).

    CAS  Article  Google Scholar 

  9. Mishima, M., Kaitna, S. & Glotzer, M. Dev. Cell 2, 41–54 (2002).

    CAS  Article  Google Scholar 

  10. Gruneberg, U., Neef, R., Honda, R., Nigg, E. A. & Barr, F. A. J. Cell Biol. 166, 167–172 (2004).

    CAS  Article  Google Scholar 

  11. Neef, R. et al. J. Cell Biol. 162, 863–875 (2003).

    CAS  Article  Google Scholar 

  12. Hornick, J. E., Karanjeet, K., Collins, E. S. & Hinchcliffe, E. H. Semin. Cell Dev. Biol. (2010).

  13. Kouranti, I., Sachse, M., Arouche, N., Goud, B. & Echard, A. Curr. Biol. 16, 1719–1725 (2006).

    CAS  Article  Google Scholar 

  14. Delevoye, C. et al. J. Cell Biol. 187, 247–264 (2009).

    CAS  Article  Google Scholar 

  15. Nakagawa, T. et al. Cell 103, 569–581 (2000).

    CAS  Article  Google Scholar 

  16. Carlton, J. G. & Martin-Serrano, J. Science 316, 1908–1912 (2007).

    CAS  Article  Google Scholar 

  17. Morita, E. et al. EMBO J. 26, 4215–4227 (2007).

    CAS  Article  Google Scholar 

  18. Dukes, J. D., Richardson, J. D., Simmons, R. & Whitley, P. Biochem. J. 411, 233–239 (2008).

    CAS  Article  Google Scholar 

  19. Hanson, P. I., Roth, R., Lin, Y. & Heuser, J. E. J. Cell Biol. 18 0, 389–402 (2008).

    Article  Google Scholar 

Download references

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Montagnac, G., Chavrier, P. Abscission accomplished by PtdIns(3)P. Nat Cell Biol 12, 308–310 (2010). https://doi.org/10.1038/ncb0410-308

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