Cytokinesis — the final step of mitosis in which the two daughter cells separate — requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.
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References
Montagnac, G., Echard, A. & Chavrier, P. Curr. Opin. Cell Biol. 20, 454–461 (2008).
Echard, A. Biochem. Soc. Trans. 36, 395–399 (2008).
Sagona, A. P. et al. Nature Cell Biol. 12, 362–371 (2010).
Lindmo, K. & Stenmark, H. J. Cell Sci. 119, 605–614 (2006).
Vermeer, J. E. et al. Plant J. 47, 687–700 (2006).
Falasca, M. & Maffucci, T. Biochim. Biophys. Acta 1793, 1795–1803 (2009).
Hanein, S. et al. Am. J. Hum. Genet. 82, 992–1002 (2008).
Kurasawa, Y., Earnshaw, W. C., Mochizuki, Y., Dohmae, N. & Todokoro, K. EMBO J. 23, 3237–3248 (2004).
Mishima, M., Kaitna, S. & Glotzer, M. Dev. Cell 2, 41–54 (2002).
Gruneberg, U., Neef, R., Honda, R., Nigg, E. A. & Barr, F. A. J. Cell Biol. 166, 167–172 (2004).
Neef, R. et al. J. Cell Biol. 162, 863–875 (2003).
Hornick, J. E., Karanjeet, K., Collins, E. S. & Hinchcliffe, E. H. Semin. Cell Dev. Biol. (2010).
Kouranti, I., Sachse, M., Arouche, N., Goud, B. & Echard, A. Curr. Biol. 16, 1719–1725 (2006).
Delevoye, C. et al. J. Cell Biol. 187, 247–264 (2009).
Nakagawa, T. et al. Cell 103, 569–581 (2000).
Carlton, J. G. & Martin-Serrano, J. Science 316, 1908–1912 (2007).
Morita, E. et al. EMBO J. 26, 4215–4227 (2007).
Dukes, J. D., Richardson, J. D., Simmons, R. & Whitley, P. Biochem. J. 411, 233–239 (2008).
Hanson, P. I., Roth, R., Lin, Y. & Heuser, J. E. J. Cell Biol. 18 0, 389–402 (2008).
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Montagnac, G., Chavrier, P. Abscission accomplished by PtdIns(3)P. Nat Cell Biol 12, 308–310 (2010). https://doi.org/10.1038/ncb0410-308
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DOI: https://doi.org/10.1038/ncb0410-308
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