Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

SOC: now also store-operated cyclase

Depletion of Ca2+ from intracellular stores has long been known to signal to and activate plasma membrane 'store-operated' channels. We now learn that store depletion also controls the formation of cyclic AMP (cAMP) through the regulation of adenylyl cyclase (A-Cyclase). These findings substantially broaden the scope and biological significance of Ca2+ store-regulated signalling.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Calcium store-operated cell signalling.

References

  1. Parekh, A. B. & Putney, J. W. Physiol. Rev. 85, 757–810 (2005).

    Article  CAS  Google Scholar 

  2. Lefkimmiatis, K. et al. Store-operated cyclic AMP signaling mediated by STIM1. Nature Cell Biol. 11, 433–442 (2009).

    Article  CAS  Google Scholar 

  3. Cahalan, M. D. et al. Cell Calcium 42, 133–144 (2007).

    Article  CAS  Google Scholar 

  4. Gwack, Y., Feske, S., Srikanth, S., Hogan, P. G. & Rao, A. Cell Calcium 42, 145–156 (2007).

    Article  CAS  Google Scholar 

  5. Vig, M. & Kinet, J. P. Cell Calcium 42, 157–162 (2007).

    Article  CAS  Google Scholar 

  6. Verkhratsky, A. & Petersen, O. H. Eur. J. Pharmacol. 447, 141–154 (2002).

    Article  CAS  Google Scholar 

  7. Putney, J. W. & Bird, G. S. J. Physiol. 586, 3055–3059 (2008).

    Article  CAS  Google Scholar 

  8. Parekh, A. B. Cell Calcium 42, 111–121 (2007).

    Article  CAS  Google Scholar 

  9. Brandman, O., Liou, J., Park, W. S. & Meyer, T. Cell 131, 1327–1339 (2007).

    Article  CAS  Google Scholar 

  10. Rasmussen, H. Science 170, 404–412 (1970).

    Article  CAS  Google Scholar 

  11. Zaccolo, M. & Pozzan, T. Trends Neurosci. 26, 53–55 (2003).

    Article  CAS  Google Scholar 

  12. Martin, A. C. & Cooper, D. M. Biochem. Soc. Trans. 34, 480–483 (2006).

    Article  CAS  Google Scholar 

  13. Varnai, P., Toth, B., Toth, D. J., Hunyady, L. & Balla, T. J. Biol. Chem. 282, 29678–29690 (2007).

    Article  CAS  Google Scholar 

  14. Csutora, P. et al. J. Biol. Chem. 283, 14524–14531 (2008).

    Article  CAS  Google Scholar 

  15. Bian, X., Hughes, F. M. Jr, Huang, Y., Cidlowski, J. A. & Putney, J. W. Am. J. Physiol. 272, C1241–C1249 (1997).

    Article  CAS  Google Scholar 

  16. Berridge, M. J. Cell Calcium 32, 235–249 (2002).

    Article  CAS  Google Scholar 

  17. Baba, Y. et al. Nature Immunol. 9, 81–88 (2008).

    Article  CAS  Google Scholar 

  18. Baba, Y. et al. Proc. Natl Acad. Sci. USA 103, 16704–16709 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Putney, J. SOC: now also store-operated cyclase. Nat Cell Biol 11, 381–382 (2009). https://doi.org/10.1038/ncb0409-381

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0409-381

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing