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SOC: now also store-operated cyclase

Nature Cell Biology volume 11, pages 381382 (2009) | Download Citation

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Depletion of Ca2+ from intracellular stores has long been known to signal to and activate plasma membrane 'store-operated' channels. We now learn that store depletion also controls the formation of cyclic AMP (cAMP) through the regulation of adenylyl cyclase (A-Cyclase). These findings substantially broaden the scope and biological significance of Ca2+ store-regulated signalling.

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Affiliations

  1. James W. Putney Jr is in the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences–NIH, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 2770, USA.  putney@niehs.nih.gov

    • James W. Putney Jr

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DOI

https://doi.org/10.1038/ncb0409-381

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