Depletion of Ca2+ from intracellular stores has long been known to signal to and activate plasma membrane 'store-operated' channels. We now learn that store depletion also controls the formation of cyclic AMP (cAMP) through the regulation of adenylyl cyclase (A-Cyclase). These findings substantially broaden the scope and biological significance of Ca2+ store-regulated signalling.
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Putney, J. SOC: now also store-operated cyclase. Nat Cell Biol 11, 381–382 (2009). https://doi.org/10.1038/ncb0409-381
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DOI: https://doi.org/10.1038/ncb0409-381