The assembly of actin networks is dependent on nucleation-promoting factors. A new study identifies JMY as a protein containing two separate nucleation-promoting activities that shuttles between the nucleus and the cytoplasm and promotes cell migration. These observations indicate that JMY is an important factor controlling actin dynamics in motile cells.
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David W. Roadcap and James E. Bear are at the Lineberger Comprehensive Cancer Center and Department of Cell & Developmental Biology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, USA. jbear@email.unc.edu
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