Phenotypic variation between tumour types is likely to reflect the nature of the cell of origin and the genes involved in pathogenesis. Compared with most sporadic breast cancers, those arising in carriers of BRCA1 mutations usually have distinctive pathological characteristics. A new study suggests that a role for BRCA1 in the determination of stem-cell fate may explain this phenomenon.
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References
Smalley, M. & Ashworth, A. Nature Rev. Cancer 3, 832–844 (2003).
Turner NC, Tutt A. & Ashworth, A. Nature Rev. Cancer 4, 814–819 (2004).
Foulkes, W. D. J. Med. Genet. 41, 1–5 (2004).
Dontu, G., El-Ashry, D. & Wicha, M. S. Trends Endocrinol. Metab. 15, 193–197 (2004).
Liu, S. et al. Proc. Natl Acad. Sci. USA 105, 1680–1685 (2008).
Ashworth, A. Cancer Cell 8, 95–97 (2005).
Hosey, A. et al. J. Natl Cancer Inst. 99, 1683–1694 (2007).
Turner, N. C. & Reis-Filho, J. S. Oncogene 25, 5846–5853 (2006).
Ginestier, C. et al. Cell Stem Cell 1, 555–567 (2007).
Novelli, M. et al. Proc. Natl Acad. Sci. USA 100, 3311–3314 (2003).
Clarke, C. et al. Br. J. Cancer 95, 515–519 (2006).
Palacios, J. et al. Breast Cancer Res. Treat. 90, 5–14 (2005).
Liu, X. et al. Proc. Natl Acad. Sci. USA 104, 12111–12116 (2007).
McCarthy, A. et al. J. Pathol. 211, 389–98 (2007).
Farmer, H. et al. Nature 434, 917–921 (2005).
Edwards, S. et al. Nature 451, 1111–1115 (2008).
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Smalley, M., Reis-Filho, J. & Ashworth, A. BRCA1 and stem cells: tumour typecasting. Nat Cell Biol 10, 377–379 (2008). https://doi.org/10.1038/ncb0408-377
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DOI: https://doi.org/10.1038/ncb0408-377
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