Bone Morphogenetic Protein (Bmp) signalling has a critical function in patterning vertebrate and invertebrate embryos. A key regulator of Bmp signalling is Chordin, which binds Bmps and prevents them from interacting with their receptors. Two new papers identify the Frizzled-related protein Sizzled as an unexpected regulator of Chordin stability.
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Kimelman, D., Szeto, D. Chordin cleavage is sizzling. Nat Cell Biol 8, 305–307 (2006). https://doi.org/10.1038/ncb0406-305
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DOI: https://doi.org/10.1038/ncb0406-305
