Monoubiquitination of the processivity clamp, PCNA, facilitates the replicative bypass of DNA lesions by recruiting damage-tolerant polymerases. In undamaged cells, deubiquitination of PCNA by the deubiquitinating enzyme USP1 reveals a possible safeguard mechanism against the mutagenic effect of these polymerases. Intriguingly, USP1 itself seems to be downregulated by a damage-induced autocatalytic cleavage event.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2
Cell Division Open Access 31 March 2011
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Woodgate, R. Genes Dev. 13, 2191–2195 (1999).
Pages, V. & Fuchs, R.P. Oncogene 21, 8957–8966 (2002).
Hoege, C. et al. Nature 419, 135–141 (2002).
Kannouche, P.L., Wing, J. Lehmann, A.R. Mol. Cell 14, 491–500 (2004).
Stelter, P. & Ulrich, H.D. Nature 425, 188–191 (2003).
Watanabe, K. et al. EMBO J. 23, 3886–3896 (2004).
Bienko, M. et al. Science 310, 1821–1824 (2005).
Garg, P. & Burgers, P.M. Proc. Natl Acad. Sci. USA 102, 18361–18366 (2005).
Huang, T.T. et al. Nature Cell Biol. 8, 339–347 (2006).
Nijman, S.M. et al. Mol. Cell 17, 331–339 (2005).
D'Andrea, A.D. Genes Dev. 17, 1933–1936 (2003).
Luo, Y. et al. Cell 106, 585–594 (2001).
Shi, Y. Cell 117, 855–858 (2004).
Niedzwiedz, W. et al. Mol. Cell 15, 607–620 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ulrich, H. Deubiquitinating PCNA: a downside to DNA damage tolerance. Nat Cell Biol 8, 303–305 (2006). https://doi.org/10.1038/ncb0406-303
Issue Date:
DOI: https://doi.org/10.1038/ncb0406-303