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PINning down the c-Myc oncoprotein

Nature Cell Biology volume 6, pages 288–289 (2004)Cite this article

The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.

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Figure 1: A finely tuned system to regulate c-Myc protein stability.

References

  1. Pelengaris, S., Khan, M. & Evan, G. Nature Rev. Cancer 2, 764–776 (2002).

    Article  CAS  Google Scholar 

  2. Dalla-Favera, R. et al. Proc. Natl Acad. Sci. USA 79, 7824–7827 (1982).

    Article  CAS  Google Scholar 

  3. Dalla-Favera, R., Wong-Staal, F. & Gallo, R.C. Nature 299, 61–65 (1982).

    Article  CAS  Google Scholar 

  4. Bhatia, K. et al. Nature Genet. 5, 56–61 (1993).

    Article  CAS  Google Scholar 

  5. Gregory, M.A. & Hann, S.R. Mol. Cell. Biol. 20, 2423–2435 (2000).

    Article  CAS  Google Scholar 

  6. Pulverer, B.J. et al. Oncogene 9, 59–70 (1994).

    CAS  PubMed  Google Scholar 

  7. Yeh, et al. Nature Cell Biol. 6, 308–318 (2004).

    Article  CAS  Google Scholar 

  8. Sears, R. et al. Genes Dev. 14, 2501–2514 (2000).

    Article  CAS  Google Scholar 

  9. Janssens, V. and Goris, J. Biochem. J. 353, 417–439 (2001).

    Article  CAS  Google Scholar 

  10. Lu, K.P., Liou, Y.C. & Zhou, X.Z. Trends Cell Biol. 12, 164–172 (2002).

    Article  CAS  Google Scholar 

  11. Ryo, A., Liou, Y.C., Lu, K.P. & Wulf, G. J. Cell Sci. 116, 773–783 (2003).

    Article  CAS  Google Scholar 

  12. Chen, W. et al. Cancer Cell 5, 127–136 (2004).

    Article  CAS  Google Scholar 

  13. Shen, M., Stukenberg, P.T., Kirschner, M.W. & Lu, K.P. Genes Dev. 12, 706–720 (1998).

    Article  CAS  Google Scholar 

  14. Matsuo, T. et al. Science 302, 255–259 (2003).

    Article  CAS  Google Scholar 

  15. Pasqualucci, L. et al. Nature 412, 341–346 (2001).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. the Institute for Cancer Genetics, Columbia University, New York, 10032, NY, USA

    David Dominguez-Sola & Riccardo Dalla-Favera

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  1. David Dominguez-Sola
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  2. Riccardo Dalla-Favera
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Dominguez-Sola, D., Dalla-Favera, R. PINning down the c-Myc oncoprotein. Nat Cell Biol 6, 288–289 (2004). https://doi.org/10.1038/ncb0404-288

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