Budding and fission yeast serve as genetic model organisms for the study of the molecular mechanisms of cell polarity in single cells. Similar to other polarized eukaryotic cells, yeast cells have polarity programmes that regulate where they grow and divide. Here, we describe recent advances in defining the proteins that establish cell polarity and the numerous molecular interactions that may link these factors to the actin cytoskeleton. As many of these components are identified, a comprehensive understanding of complex pathways is beginning to emerge.
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We thank the many colleagues who contributed unpublished results and Y. Barral, M. Gotta. Work in the laboratory of M.P. is supported by the SNF and the ETHZ. F.C. is supported by grants from the National Institutes of Health, American Cancer Society, March of Dimes and the Hirschl Trust.
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