The coordinated action of several conserved multiprotein complexes establishes polarity in an asymmetrically dividing cell. How apically localized cues affect the basal distribution of proteins has remained unclear. However, new studies provides a direct link between the two poles, showing that the apical Par6–aPKC complex directly regulates Lethal giant larvae (Lgl).
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Justice, N., Jan, Y. A lethal giant kinase in cell polarity. Nat Cell Biol 5, 273–274 (2003). https://doi.org/10.1038/ncb0403-273
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DOI: https://doi.org/10.1038/ncb0403-273