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Integrin regulation of growth factor receptors

Integrins are receptors for extracellular matrix proteins that engage in reciprocal crosstalk with growth factor receptors. Recent work identifies a unique mechanism for the regulation of growth factor receptor phosphorylation by integrins, indicating multiple ways of achieving cooperation between these major signalling systems.

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Figure 1: Integrin collaboration compared to direct integrin 'activation' of growth factor receptors.

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Yamada, K., Even-Ram, S. Integrin regulation of growth factor receptors. Nat Cell Biol 4, E75–E76 (2002). https://doi.org/10.1038/ncb0402-e75

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