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Herpesvirus hijacks an integrin

Nature Cell Biology volume 4, pages E69–E71 (2002)Cite this article

Human herpesvirus 8 (HHV-8), an agent associated with Kaposi's sarcoma, binds to integrin α3β1 through its gB envelope glycoprotein, and thus gains entry into human fibroblasts. Based on an analogy with other microbial pathogens, integrin interaction with HHV-8 may induce signalling events that promote cell entry and perhaps facilitate disease progression.

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Figure 1: A schematic representation of the HHV-8–integrin α3β1 interaction and the subsequent cell signalling events.
Figure 2: Examples of cell integrins used for cell entry by enveloped and non-enveloped animal viruses.

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Authors and Affiliations

  1. Department of Immunology, The Scripps Research Institute, La Jolla, 92037, California, USA

    Glen R. Nemerow & David A. Cheresh

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  1. Glen R. Nemerow
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  2. David A. Cheresh
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Nemerow, G., Cheresh, D. Herpesvirus hijacks an integrin. Nat Cell Biol 4, E69–E71 (2002). https://doi.org/10.1038/ncb0402-e69

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