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Teaching tumour suppressors new tricks

Abstract

Examination of the tumour suppressor adenomatous polyposis coli (APC) has shown that it may be multifunctional. Recent work has demonstrated dynamic interactions of APC with the microtubule cytoskeleton, supporting the idea that APC has an important function in cell migration.

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Figure 1: The many functions of APC.

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Correspondence to Brooke M. McCartney.

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McCartney, B., Peifer, M. Teaching tumour suppressors new tricks. Nat Cell Biol 2, E58–E60 (2000). https://doi.org/10.1038/35008685

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