Abstract
Examination of the tumour suppressor adenomatous polyposis coli (APC) has shown that it may be multifunctional. Recent work has demonstrated dynamic interactions of APC with the microtubule cytoskeleton, supporting the idea that APC has an important function in cell migration.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Peifer, M. & Polakis, P. Science 287, 1606-1609 (2000).
Mimori-Kiyosue, Y., Shiina, N. & Tsukita, S. J. Cell Biol. 148, 505-518 (2000).
Munemitsu, S. et al. Cancer Res. 54, 3676– 3681 (1994).
Smith, K. J. et al. Cancer Res. 54, 3672– 3675 (1994).
Nathke, I. S., Adams, C. L., Polakis, P., Sellin, J. H. & Nelson, W. J. J. Cell Biol. 134, 165–179 (1996).
Schliwa, M., Euteneuer, U., Gräf, R. & Ueda, M. Biochem. Soc. Symp. 65, 223–231 (1999).
McCartney, B. M. et al. J. Cell. Biol. 146, 1303– 1318 (1999).
Yu, X., Waltzer, L. & Bienz, M. Nature Cell Biol. 1, 144– 151 (1999).
Smits, R. et al. Genes Dev. 13, 1309–1321 (1999).
Barth, A. I., Pollack, A. L., Altschuler, Y., Mostov, K.E. & Nelson, W.J. J. Cell Biol. 136, 693–706 (1997).
Pollack, A. L., Barth, A. I. M., Altschuler, Y., Nelson, W. J. & Mostov, K. E. J. Cell Biol. 137, 1651–1662 (1997).
Miller, J. R. et al. J. Cell Biol. 146, 427– 437 (1999).
Su, L. K. et al. Cancer Res. 55, 2972– 2977 (1995).
Berrueta, L. et al. Proc. Natl Acad. Sci. U S A 95, 10596 –10601 (1998).
Berrueta, L., Tirnauer, J. S., Schuyler, S. C., Pellman, D. & Bierer, B. E. Curr. Biol. 9, 425–428 (1999).
Morrison, E. E., Wardleworth, B. N., Askham, J. M., Markham, A. F. & Meredith, D. M. Oncogene 17, 3471–3477 (1998).
Beinhauer, J. D., Hagan, I. M., Hegemann, J. H. & Fleig, U. J. Cell Biol. 139, 717–728 (1997).
Schwartz, K., Richards, K. & Botstein, D. Mol. Biol. Cell. 8, 2677– 2691 (1997).
Muhua, L., Adames, N. R., Murphy, M. D., Shields, C. R. & Cooper, J. A. Nature 393, 487–491 (1998).
Lengauer, C., Kinzler, K. W. & Vogelstein, B. Nature 386, 623– 627 (1997).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
McCartney, B., Peifer, M. Teaching tumour suppressors new tricks. Nat Cell Biol 2, E58–E60 (2000). https://doi.org/10.1038/35008685
Issue Date:
DOI: https://doi.org/10.1038/35008685
This article is cited by
-
Epithelial proliferation induces novel changes in APC expression
Oncogene (2005)
-
Identification of a link between the tumour suppressor APC and the kinesin superfamily
Nature Cell Biology (2002)
-
Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
Nature Cell Biology (2001)
-
A role for the Adenomatous Polyposis Coli protein in chromosome segregation
Nature Cell Biology (2001)
-
It’s a kar9ochore to capture microtubules
Nature Cell Biology (2000)