PTH battles TGF-β in bone

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Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-β). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-β type II receptor (TβRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-β and PTH signalling in vivo.

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Figure 1: PTH induces the internalization of TβRII–PTH1R complexes and attenuates PTH and TGF-β signalling.

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Correspondence to Azeddine Atfi.

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