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The peroxisomal protein importomer: a bunch of transients with expanding waistlines

Nature Cell Biology volume 12, pages 203–205 (2010)Cite this article

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Peroxisomes can import large multimeric protein complexes and even 9-nm gold particles decorated with peroxisome-targeting signals. They achieve these feats of protein passage using a distinctive translocon whose highly dynamic aqueous pore can expand to accommodate the increasing girths of different peroxisome receptor–cargo complexes.

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Figure 1: A planar lipid bilayer assay can be used to demonstrate the induction of an expandable and transient peroxisomal translocon channel by cargo-laden Pex5p.

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Authors and Affiliations

  1. Andrei Fagarasanu and Richard Rachubinski are in the Department of Cell Biology, Fred D. Mast, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.,

    Fred D. Mast, Andrei Fagarasanu & Richard Rachubinski

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  1. Fred D. Mast
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  2. Andrei Fagarasanu
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  3. Richard Rachubinski
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Correspondence to Richard Rachubinski.

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Mast, F., Fagarasanu, A. & Rachubinski, R. The peroxisomal protein importomer: a bunch of transients with expanding waistlines. Nat Cell Biol 12, 203–205 (2010). https://doi.org/10.1038/ncb0310-203

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