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Untangling the signalling wires

Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF–MEK–ERK cascade induced by two different growth factors. The study shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.

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Figure 1: EGF stimulation of PC12 cells leads to proliferation, whereas the response to NGF is differentiation into neurons.


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Kholodenko, B. Untangling the signalling wires. Nat Cell Biol 9, 247–249 (2007).

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