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The Myc trilogy: lord of RNA polymerases

Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.

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Figure 1: Proteins and rRNAs synthesized by all three RNA polymerases (RNA Pol I, II and III) are necessary for the generation of ribosomes.
Figure 2: Model for the simultaneous control of cell growth and division.

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Oskarsson, T., Trumpp, A. The Myc trilogy: lord of RNA polymerases. Nat Cell Biol 7, 215–217 (2005). https://doi.org/10.1038/ncb0305-215

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