The assembly of the DNA helicase at replication origins is crucial in initiating DNA synthesis. This process requires the conserved protein Cdt1. Here, a new study identifies a functional homologue of Cdt1 in Saccharomyces cerevisiae. The regulation of its activity reveals an alternative way to assemble prereplicative complexes (pre-RCs) and regulate origin function.
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Maiorano, D., Méchali, M. Many roads lead to the origin. Nat Cell Biol 4, E58–E59 (2002). https://doi.org/10.1038/ncb0302-e58
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DOI: https://doi.org/10.1038/ncb0302-e58
