Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
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Jones, K. Cohesin and Cdk1: an anaphase barricade. Nat Cell Biol 12, 106–108 (2010). https://doi.org/10.1038/ncb0210-106
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DOI: https://doi.org/10.1038/ncb0210-106
