Nerve growth factor induces sensory neuron survival via retrograde signalling from the axon to the cell body. Local translation of the transcription factor CREB in the axon, followed by its transport to the nucleus, is involved in this process.
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Lin, A., Holt, C. Outsourcing CREB translation to axons to survive. Nat Cell Biol 10, 115–118 (2008). https://doi.org/10.1038/ncb0208-115
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DOI: https://doi.org/10.1038/ncb0208-115
