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Outsourcing CREB translation to axons to survive

Nature Cell Biology volume 10, pages 115118 (2008) | Download Citation

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Nerve growth factor induces sensory neuron survival via retrograde signalling from the axon to the cell body. Local translation of the transcription factor CREB in the axon, followed by its transport to the nucleus, is involved in this process.

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Author information

Affiliations

  1. Andrew C. Lin and Christine E. Holt are in the Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom.  al404@cam.ac.uk

    • Andrew C. Lin
    •  & Christine E. Holt

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DOI

https://doi.org/10.1038/ncb0208-115

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