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The pRb–Cdh1–p27 autoamplifying network

Nature Cell Biology volume 9, pages 137–138 (2007)Cite this article

In proliferating cells, the SCFSkp2ubiquitin ligase targets the CDK inhibitor p27 for proteolysis. A study now shows that the tumour suppressor pRb promotes the APC/CCdh1–mediated degradation of Skp2, resulting in the accumulation of p27.

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Figure 1: Cell proliferation is tightly controlled by a large number of regulators, some of which are depicted in this schematic representation.

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Authors and Affiliations

  1. Department of Pathology, New York University School of Medicine and NYU Cancer Institute, MSB 599, 550 First Avenue, New York, 10016, NY, USA

    Patricia G. Santamaría & Michele Pagano

Authors
  1. Patricia G. Santamaría
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  2. Michele Pagano
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Santamaría, P., Pagano, M. The pRb–Cdh1–p27 autoamplifying network. Nat Cell Biol 9, 137–138 (2007). https://doi.org/10.1038/ncb0207-137

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