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Luminal cells GATA have it

The transcription factor GATA-3 is necessary for the formation of a mammary gland and the maintenance of mammary-cell differentiation. The loss of GATA-3 function in a fully formed mammary gland generates oestrogen receptor-negative, proliferating cells that lack expression of myoepithelial markers. Cells with similar characteristics in breast cancer are associated with poor prognosis.

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Figure 1: A schematic representation of a proposed epithelial hierarchy for the generation of oestrogen receptor-negative tumours.

References

  1. Britten R. J. & Davidson E. H. Science 165, 349–357 (1969).

    Article  CAS  Google Scholar 

  2. Kouros-Mehr, H., Slorach, E. M., Sternlicht, M. D. & Werb, Z. Cell 127, 1041–1055 (2006).

    Article  CAS  Google Scholar 

  3. Asselin-Labat, M.L. et al. Nature Cell Biol. 9, 201–209 (2007).

    Article  CAS  Google Scholar 

  4. Burch J. B. Semin. Cell Dev. Biol. 16, 71–81 (2005).

    Article  CAS  Google Scholar 

  5. Galloway, J. L. et al. Dev. Cell 8, 109–116 (2005).

    Article  CAS  Google Scholar 

  6. Shackleton, M. et al. Nature 439, 84–88 (2006).

    Article  CAS  Google Scholar 

  7. Stingl, J. et al. Nature 439, 993–997 (2006).

    Article  CAS  Google Scholar 

  8. Oh, D. S. et al. J. Clin. Oncol. 24, 1656–1664 (2006).

    Article  CAS  Google Scholar 

  9. Mehra, R. et al. Cancer Res. 65, 11259–11264 (2005).

    Article  CAS  Google Scholar 

  10. Kesse-Adu, R. & Shousha, S. Mod Pathol. 17, 646–652 (2004).

    Article  CAS  Google Scholar 

  11. Usary, J. et al. Oncogene 23, 7669–7678 (2004).

    Article  CAS  Google Scholar 

  12. Guo, M. et al. Int. J. Cancer. 119, 2078–2083 (2006).

    Article  CAS  Google Scholar 

  13. Caslini, C. et al. Oncogene 25, 5446–5461 (2006).

    Article  CAS  Google Scholar 

  14. Chun, T. H. et al. Circ Res. 92, 1201–1208 (2003).

    Article  CAS  Google Scholar 

  15. Hosokawa, H. et al. J. Immunol. 177, 7656–7664 (2006).

    Article  CAS  Google Scholar 

Download references

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Tlsty, T. Luminal cells GATA have it. Nat Cell Biol 9, 135–136 (2007). https://doi.org/10.1038/ncb0207-135

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