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V-ATPase: a potential pH sensor

An interaction between V-ATPase, a multi-subunit complex responsible for endosome acidification, and ARNO, the GDP/GTP exchange factor for ARF1 and ARF6, indicates that V-ATPase is the long-sought pH-sensor that regulates trafficking in the endocytic pathway.

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Figure 1: V-ATPase-dependent regulation of endocytic trafficking.

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Recchi, C., Chavrier, P. V-ATPase: a potential pH sensor. Nat Cell Biol 8, 107–109 (2006). https://doi.org/10.1038/ncb0206-107

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