An interaction between V-ATPase, a multi-subunit complex responsible for endosome acidification, and ARNO, the GDP/GTP exchange factor for ARF1 and ARF6, indicates that V-ATPase is the long-sought pH-sensor that regulates trafficking in the endocytic pathway.
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References
Gruenberg, J. Nature Rev. Mol. Cell Biol. 2, 721–730 (2001).
Nishi, T. & Forgac, M. Nature Rev. Mol. Cell Biol. 3, 94–103 (2002).
Hurtado-Lorenzo, A. et al. Nature Cell Biol. 8, 124–136 (2006).
Clague, M.J., Urbe, S., Aniento, F. & Gruenberg, J. J Biol Chem 269, 21–24 (1994).
van Weert, A.W. et al. J. Cell Biol. 130, 821–834 (1995).
Aniento, F., Gu, F., Parton, R.G. & Gruenberg, J. J. Cell Biol. 133, 29–41 (1996).
Whitney, J.A. et al. Cell 83, 703–713 (1995).
Gu, F. & Gruenberg, J. J. Biol. Chem. 275, 8154–8160 (2000).
Zeuzem, S. et al. Proc Natl Acad Sci USA 89, 6619–6623 (1992).
Gekle, M. Annu. Rev. Physiol. 67, 573–594 (2005).
Maranda, B. et al. J. Biol. Chem. 276, 18540–18550 (2001).
Chavrier, P. & Goud, B. Curr. Opin. Cell Biol. 11, 466–475 (1999).
Jackson, C.L. & Casanova, J.E. Trends Cell Biol. 10, 60–67 (2000).
Frank, S., Upender, S., Hansen, S.H. & Casanova, J.E. J. Biol. Chem. 273, 23–27 (1998).
Macia, E., Chabre, M. & Franco, M. J. Biol. Chem. 276, 24925–24930 (2001).
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Recchi, C., Chavrier, P. V-ATPase: a potential pH sensor. Nat Cell Biol 8, 107–109 (2006). https://doi.org/10.1038/ncb0206-107
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DOI: https://doi.org/10.1038/ncb0206-107
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