The kinetochore attaches the centromeric region of chromosomes to spindle microtubules, allowing equatorial chromosome segregation during mitosis. Proteomic analyses suggest that the kinetochore is a supramolecular complex containing more than 65 proteins that surpasses the size of a ribosome. From within this complex web, stable protein sub-complexes have been extracted, revealing the building blocks for kinetochore assembly.
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Measday, V., Hieter, P. Kinetochore sub-structure comes to MIND. Nat Cell Biol 6, 94–95 (2004). https://doi.org/10.1038/ncb0204-94
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DOI: https://doi.org/10.1038/ncb0204-94
