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'Rab'ing up endosomal membrane transport

Early endosomes are the first sorting station from which endocytosed materials are targeted to various intracellular destinations. Recent work has identified the FYVE-domain protein rabenosyn-5 as a bifunctional effector of the GTPases rab5 and rab4, physically connecting entry and recycling sites on early endosomes.

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Figure 1
Figure 2: Proposed model for the bivalent effector function of rabenosyn-5 connecting rab5 and rab4 domains on early endosomes.


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Deneka, M., van der Sluijs, P. 'Rab'ing up endosomal membrane transport. Nat Cell Biol 4, E33–E35 (2002).

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