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Death by design: the big debut of small molecules

Nature Cell Biology volume 3, pages E43–E45 (2001)Cite this article

Members of the Bcl-2 family are critical regulators of apoptosis and have become attractive targets for the development of anti-cancer drugs. The latest discovery of small-molecule inhibitors of Bcl-2 proteins may provide the sought-after leads for the development of new anti-cancer therapy

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Figure 1: Sensitization of cancer cells to apoptosis through targeting of Bcl-2-like proteins.
Figure 2: Generation of high-affinity small-molecule ligands.

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  1. Biogen Inc., 14 Cambridge Center, Cambridge, 02142, Massachusetts, USA

    Timothy S. Zheng

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  1. Timothy S. Zheng
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Zheng, T. Death by design: the big debut of small molecules. Nat Cell Biol 3, E43–E45 (2001). https://doi.org/10.1038/35055145

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