Most cells can rapidly repair extensive tears in their plasma membrane, a response dependent on extracellular calcium. Entry of extracellular oxidants through a membrane disruption oxidizes and thus activates a newly discovered membrane repair protein, MG53, in skeletal muscle cells.
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McNeil, P. Membrane repair redux: redox of MG53. Nat Cell Biol 11, 7–9 (2009). https://doi.org/10.1038/ncb0109-7
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DOI: https://doi.org/10.1038/ncb0109-7
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