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Epigenetic memory: H3.3 steps in the groove

Nature Cell Biology volume 10, pages 79 (2008) | Download Citation

Successful animal cloning after nuclear transfer requires efficient reprogramming to achieve totipotency. Erasure of pre-existing marks is not always efficient and some genes can escape reprogramming and maintain their original active transcriptional state. Ng and Gurdon propose that the histone H3.3 variant is a key player in this process.

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Affiliations

  1. Nicolas Lacoste and Geneviève Almouzni are at the Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 CNRS/Institut Curie 26, Rue d'Ulm, 75248 Paris Cedex 5, France.  genevieve.almouzni@curie.fr

    • Nicolas Lacoste
    •  & Geneviève Almouzni

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DOI

https://doi.org/10.1038/ncb0108-7

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